Impurities

S.No Impurity Name Structure CAS No
1 Amlodipine EP Impurity A 88150-62-3
2 Amlodipine EP Impurity B 721958-72-1
3 Amlodipine EP Impurity C 721958-74-3
4 Amlodipine EP Impurity D 1216406-90-4
5 Amlodipine EP Impurity E 140171-65-9
6 Amlodipine EP Impurity F 140171-66-0
7 Amlodipine EP Impurity G 43067-01-2
8 Amlodipine EP Impurity A 318465-73-5
S.No Impurity Name Structure CAS No
9 Aripiprazole EP Impurity A 22246-18-0
10 Amlodipine EP Impurity B 119532-26-2
11 Amlodipine EP Impurity C 203395-81-7
12 Amlodipine EP Impurity D 203395-82-8
13 Amlodipine EP Impurity D 129722-25-4
14 Amlodipine EP Impurity D 573691-09-5
S.No Impurity Name Structure CAS No
15 Tetrahydro imp
16 Cis -Asenapine
17 N-oxide IMP 1367373-77-0
18 Deschloro
19 Amide IMP (ASM-6) 934996-79-9
S.No Impurity Name Structure CAS No
20 ANZ-1 / Imp-C (EP) 120511-84-4
21 IMP-D (EP) Dibromo 1027160-12-8
S.No Impurity Name Structure CAS No
22 CABS-1
23 FADCP IMP 171887-03-9
24 IMP-C 172015-79-1
25 CABS-2 172721-00-5
26 CABS-3 (API) 136470-78-5
27 DADCP
28 O-Pyrimidyl IMP / Imp-B (EP) 1443421-69-9
29 O-Acetyl IMP
30 Conbovir
31 Conbovir
32 Deschloro N,N-dimethyl
33 Amino Acid
34 Methyl Ester Imp
S.No Impurity Name Structure CAS No
35 HP-2 (Dihydroxy) Impurity 109882-30-6
36 Methyl Ester Imp 109882-25-9
37 BEN-2A / Imp-C (EP) 1313020-25-5
38 DCE imp / N-Alkylated impurity 1219709-86-0/1797881-48-1 (HCl salt)
S.No Impurity Name Structure CAS No
39 BZA-2 Impurity
40 BZA-1 Impurity
41 Dihydroxy Indole Impurity
42 BAN-1/BZX Impurity 198479-63-9
43 BZA-3 198481-32-2
44 CMX or BAZ-3 223251-25-0
S.No Impurity Name Structure CAS No
45 BRO-3 Dibromo
46 BRO-3 Dibromo
47 BRO-2A
S.No Impurity Name Structure CAS No
48 CCX1 Impurity / Imp-H (EP) 170791-09-0
49 CDS-7 / Candesartan CilexetilAPI 145040-37-5
50 CDS-7 Ethyl ester / Imp-A (EP) 139481-58-6
51 CDS-6 / Candesartan 139481-59-7
52 CDS-5/ Imp-I (EP) 139481-69-9
53 N- Ethyl impurity / Imp-E (EP) 914613-35-7
54 Des ethyl / Imp-B (EP) 86963-11-8
S.No Impurity Name Structure CAS No
55 Amide Imp. / Imp-A (EP) 64372-56-1
56 Acid Impurity / Imp-M (EP) 440121-09-5
57 Carboximide Impurity / Imp-A (EP) 64372-56-1
S.No Impurity Name Structure CAS No
58 CAP5/Impurity-3 / Imp-C (EP) 161599-46-8
59 CAP6/Impurity-4 / Imp-G (EP) 162204-20-8
60 Related Compound-A / Imp-A (EP) 66335-38-4
61 Related Compound-C 921769-65-5
62 Imp-1 CAP7 / Imp-D (EP) 910129-15-6
63 CAP7 Impurity-2 / Imp-E (EP) 162204-30-0
S.No Impurity Name Structure CAS No
64 CXB-Mme / RC-A (USP) / Imp-A (EP) 170570-01-1
65 CXB-Ome / Imp-C (EP) 170569-99-0
66 CXB-Ome / Imp-C (EP) 170569-99-0
67 Diketoschiff's base II Impurity
68 CXB RegioIsomer / Imp-B (EP) 331943-04-5
69 Celecoxib (API) 169590-42-5
70 Diketo 910303-54-7
71 Hydrazine (HBS) 17852-52-7
S.No Impurity Name Structure CAS No
72 CBA Imp 170570-01-1
73 10 DAB III Impurity
74 N-Formyl Impurity
75 TSC-1 Impurity
76 N-Acyl Impurity
77 Di BOC Impurity
70 Diketo 910303-54-7
78 Amino Alcohol Impurity 1638286-64-2
79 CBT-1(CBT-2A) 1373171-12-0
80 CBT-1A 183133-94-0
81 TSC-4
82 CBT-2 (CBT-3A) / API 183133-96-2
S.No Impurity Name Structure CAS No
83 CNL-1 Regio Isomer 170570-01-1
84 CNL-2 / API 364782-34-3
S.No Impurity Name Structure CAS No
85 N-Methyl Loratadine / Imp-G (EP) / RC-B (USP) 38092-89-6
S.No Impurity Name Structure CAS No
86 DesAcetyl imp / Imp-F (EP) 75472-91-2
87 L-Lactam /Imp-E (EP) 42399-49-5
88 ZEM-1 / Imp-B (EP) 87447-47-0
S.No Impurity Name Structure CAS No
89 Alpha - Decitabine 22432-95-7
90 DEC-1(Mixture of a, ß-Diastereomers)
91 DLB-1/Nirosulphoxide Impurity 142384-07-4
S.No Impurity Name Structure CAS No
92 DLB-1/Nirosulphoxide Impurity 142384-07-4
93 S-isomer & DLB -2 138530-95-7
94 S-isomer of Nitro Lansoprazole
95 Nitro Sulphone imp Lansoprazole)DLB-1
S.No Impurity Name Structure CAS No
96 APS / Imp-D (EP) 1614255-34-3
S.No Impurity Name Structure CAS No
97 Imp-D / Citalopram EP Impurity A 64372-56-1
99 Imp-B / RC-II 488787-59-3
99 R-Isomer 219861-53-7
S.No Impurity Name Structure CAS No
100 Imp-C (EP) 148891-53-6
101 R-isomer 138680-08-7
102 CHO / Imp-B (EP) 43200-81-3
103 N-oxide / Imp-A (EP) 43200-96-0
S.No Impurity Name Structure CAS No
104 NOME-1(sulphide) / Imp-C (EP) 73590-85-9
105 IMP-A (EP) 37052-78-1
106 Des methoxy imp / Imp-B (EP) 110374-16-8
107 Sulphone imp / Imp-D (EP) 88546-55-8
108 N-Oxide imp / Imp-E (EP) 176219-04-8
109 R-Isomer / Imp-F (EP) 119141-89-8
110 EMN-1 Nitro sulphone
S.No Impurity Name Structure CAS No
111 FIM6 or FIM6D
112 FIM8 / API 162359-56-0
113 N,N-dimehtyl Imp 1404433-87-9
114 FIM8 mono Methyl Imp 1404233-80-2
115 FIM8 Heptane Imp / Imp-B (EP) 745767-97-9
116 FIM6 Hydroxy Imp 899822-99-2
117 EMN-1 Nitro sulphone 746594-44-5
118 FIM6 mono hydroxy Imp
119 Nonane imp
120 Heptane imp
S.No Impurity Name Structure CAS No
121 IMT-1 / API 152459-95-5
122 Imp-C (EP) 404844-02-6x
123 Imp-D (EP)
124 Imp-A / Nilotinib Impurity 123367-26-0
125 Imp-F (EP) 152460-10-1
126 N,N-Dioxide imp 571186-93-1
127 Imp-2 1356565-46-2
128 Imp-1 106261-48-7
129 N,N - Dioxide 571186-93-1
130 Imp-J (EP) 571186-91-9
S.No Impurity Name Structure CAS No
131 LIN-1 / RC-C (USP) 168828-90-8
132 LIN-1 R-Isomer / DesacetamidePhthalimide (R)-Isomer 168828-89-5
133 Diphthalimide impurity 1798014-14-8
S.No Impurity Name Structure CAS No
134 R-Isomer / Imp-D (EP) 168828-90-8
135 Chloramide Imp / RC-A (USP) 102767-31-7
S.No Impurity Name Structure CAS No
136 LUR-1A
137 LUB Imp 14805-29-9
138 LUB endo Imp
139 LUD Imp 173658-50-9 
140 LRA-2 / API 367514-87-2 / 367514-88-3
141 PBI Imp  55745-83-0
S.No Impurity Name Structure CAS No
142 LAC-1/ S-ISOMER / Imp-F (EP) 175481-38-6
143 LAC-1/ DES ACETYL des methyl impurity 175481-39-7
S.No Impurity Name Structure CAS No
144 Imp-A(EP) / Ranitidine EP Impurity L 54252-45-8
145 Imp-H DIS (EP) 27507-28-4
146 Imp-G BisNizatidine (EP) 1193434-63-7
147 Imp-H (EP) 27507-28-4
S.No Impurity Name Structure CAS No
148 NRT Imp-A (IMP-1)
149 Acid (IMP-2) 874583-40-1
150 N-oxide (IMP-3) 1159977-52-2
151 NRT3
152 NRT4
153 NRT2/ Imp-2 Iodide
154 NRT-1
155 AMB
156 APP
S.No Impurity Name Structure CAS No
157 Nat/ Cis imp /Nateglinide USP Related Compound C 105816-06-6
158 NataglinideAPI (Form-B) 105816-04-4
S.No Impurity Name Structure CAS No
159 IMP - K 77301-42-9
160 ETHYL ESTER OF NAP-5/ Imp-F (EP) 31220-35-6
161 1.21 RRT IMP/ dimer
S.No Impurity Name Structure CAS No
162 Dimer imp
163 AMIDE IMP 24248-49-5
S.No Impurity Name Structure CAS No
164 Related comp-A (USP) 849206-43-5
165 Ethyl analogue 1378863-74-1
166 Imp-A (EP)/Acid imp 144689-24-7
167 Imp-C (EP)/Dehydro imp 879562-26-2
168 Mesylated coupled imp PGS-S (Related compound -3) / IMP-C (EP) 952188-00-0
169 PGR-2 (IMINO IMP) 105355-26-8
170 PIO-IIA
S.No Impurity Name Structure CAS No
171 heptadeconate/sterate 1404053-62-8
172 Octadecanoate/sterate 1172995-13-9
173 Penta decanoate 1404053-61-7
174 PAP-N-Oxide 761460-08-6
175 PAP-N-Oxide 761460-08-6
176 FPN-1
177 Keto-Hcl 1189516-65-1
178 1-Acetyl-4-(2,4-difluorobenzoyl piperidine)
S.No Impurity Name Structure CAS No
179 QUE S-oxide imp/IMP-S (EP) 329216-63-9
180 QFT /Dimer imp/IMP-D (EP) 945668-94-0
181 N-oxide/IMP-H (EP) 1076199-40-0
182 Dimer/IMP-D (EP) 945668-94-0
183 Desethanol imp/IMP-I 329216-67-3
184 QFT/Imp-2.8 RRT/imp-E (EP) 1371638-05-9
S.No Impurity Name Structure CAS No
185 chloro allyl imp 1175018-73-1
186 1-Indanone 83-33-0
187 Allyl imp 91639-43-9
188 S-isomer 202464-89-9 Freebase: 185517-74-2
189 KETO IMP 1312077-05-6
S.No Impurity Name Structure CAS No
190 5-RLZ 752969-85-0
191 4-RLZ 235101-36-7
192 Bromo-RLZ 144631-82-3
S.No Impurity Name Structure CAS No
193 RNB-1/ Ranolazine USP Related Compound A 2210-74-4
194 RNB-2 DIMER 333749-57-8
195 RNB-3 DIMER / Ranolazine USP Related Compound D 380204-72-8
196 RNB-3A (LAM) 5294-61-1
S.No Impurity Name Structure CAS No
197 L-valine derivative
198 Imp-D/NCT dimer imp 144142-33-6
199 RIT-imp-J 162849-95-8
200 IMP-L 256328-82-2
201 Imp-T/Bis-Rit imp 869368-48-9
202 TMN
203 RIT-1 165315-97-9
204 RAX 144163-85-9
205 IPZ/IMP-A 154212-61-0
S.No Impurity Name Structure CAS No
206 2NPPD
207 Desfluoro RTM-1
208 3 fluoro RTM-1
S.No Impurity Name Structure CAS No
209 Imp D (EP) 1357931-55-5
210 Des methyl Imp 139755-82-1
211 N-ethyl Imp 642928-07-2
S.No Impurity Name Structure CAS No
212 BSL-V / Imp-B (EP) 52758-05-1
213 SET-V (S, S- Isomer) 79559-97-0
214 SET-2 Trans / (1R,4S)-Sertraline HCl 79896-32-5
215 SET-2/2,3-dichloro imp 1198084-29-5
216 Sertraline (API)/ SET-V 79559-97-0
217 Imp-G (EP) / CIS(-) SETimp 79645-15-1
S.No Impurity Name Structure CAS No
218 SIT-4A 762240-92-6
219 OFT-1 764667-65-4
220 STP-4A ACID 1204818-19-8
221 STP-1
S.No Impurity Name Structure CAS No
222 TOT-monomer imp / Imp-E (EP) 194482-41-2
S.No Impurity Name Structure CAS No
223 TIC-2A (Des Acetonide) 1354945-69-9
224 TIC-2A(TIC-1) 376608-74-1
225 TIC-5A 274693-27-5
226 TIC-5A sulphoxide 1644461-85-7
227 TIC-5A sulphone 274693-39-9
228 TIC-4A (Amine) Related compound-60
229 TIC-5A (Amine) RC-45
230 TIC-5A (DE) 220347-05-7
S.No Impurity Name Structure CAS No
231 Related compound A (USP) 137862-87-4
232 Related compound B (USP) 952652-79-8
233 Related compound E (USP) / Methyl ester imp 137863-17-3
234 L-Iso leucine 137862-78-3
235 Valsartan USP Related Compound C / VAL-Benzyl imp 137863-20-8
S.No Impurity Name Structure CAS No
236 6-Chloro Voriconazole / VOZ-1 diasteromer 188416-35-5
237 Fluconazole EP Imp-E / Voriconazole EP Imp-A 86404-63-9
238 VNZ-3
239 Voriconazole (API) / VNZ-4 137234-62-9
240 Imp E 5872-8-2
241 Imp-B (EP) / RC-B / other isomer of Voriconazole 182369-73-9
242 Realated compound-A/ VOZ-2 Diastereomer
243 6-Chloro Voriconazole / VNZ-1 188416-35-5
244 VNZ-2 / API 137234-62-9
S.No Impurity Name Structure CAS No
245 Ganciclovir imp 82410-32-0 
246 Guanine imp 73-40-5
247 RC-C (USP) / methoxy methyl imp 1202645-50-8
248 Valganciclovir N-Benzyloxycarbonyl Impurity / VCR-2 194154-40-0
249 VCR-1 130914-77-1
S.No Impurity Name Structure CAS No
250 Imp-C / Vilazodone N-Oxide
251 VilazodoneCarboxy Acid / VHL ACID Imp 163521-19-5
252 BFC
253 N-FORMYL
254 VHL DIMER IMP-18
S.No Impurity Name Structure CAS No
255 ZAF-3MTSA Related Compound-E
256 ZAF-3PTSA Related Compound-C
258 MAM Acid
259 ZAF-1 MCF
260 ZAF-2
261 ZAF-1 A (1A) imp
# Name of the Impurity CAS NO
1 N-Nitrosodimethylamine 62-75-9
2 N-Nitrosodiethylamine 55-18-5
3 N-Nitrosodiisopropylamine 601-77-4
4 N-Isopropyl-N-methylnitrousamide 30533-08-5
5 N-Ethyl-N-nitroso-2-propanamine 16339-04-1
6 N-Nitroso-N-methyl-4-aminobutyric Acid 61445-55-4
7 N-Nitrosodiethylamine 55-18-5
8 N-Nitrosomorpholine 59-89-2
9 N-Nitrosopiperidine 100-75-4
10 N-Nitrosodiphenylamine 86-30-6